Bacterial translocation and intestinal injury in experimental necrotizing enterocolitis model
نویسندگان
چکیده
منابع مشابه
FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
BACKGROUND Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that primarily affects premature infants. It is characterized by inflammation and leukocyte infiltration that can progress to intestinal necrosis, perforation, systemic inflammatory response, and death. In this study, we examined the effect of FLLL32, a curcumin analog, on an NEC-like neonatal intestinal injury...
متن کاملExperimental and Clinical Necrotizing Enterocolitis
Högberg, N. 2013. Experimental and Clinical Necrotizing Enterocolitis. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 898. 47 pp. Uppsala. ISBN 978-91-554-8655-6. Necrotizing enterocolitis (NEC), a severe inflammatory disorder of the gastrointestinal tract with high morbidity and mortality, affects primarily preterm infants....
متن کاملIschaemic enterocolitis Infarction of the intestinal tract Intestinal gangrene Haemorrhagic enterocolitis Neonatal necrotizing enterocolitis Uraemic enterocolitis
A supply of oxygenated blood appropriate to the tissue needs of the gut is essential to the maintenance of its vital functions. The splanchnic vascular system serves this purpose and much of our knowledge of ischaemic bowel disease has developed from studies of radiological and pathological abnormalities of this system. The purpose of this paper is to summarize current information concerning th...
متن کاملHelicobacter hepaticus increases intestinal injury in a rat model of necrotizing enterocolitis.
Enterohepatic helicobacter species (EHS) infect the intestinal tract and biliary tree, triggering intestinal and hepatic disorders. Helicobacter hepaticus, the prototypic murine EHS, is also associated with inflammation. Necrotizing enterocolitis (NEC) is a devastating disease of premature infants. The cause of NEC is not fully understood, but anomalies of bacterial colonization (dysbiosis) are...
متن کاملNeonatal intestinal dysbiosis in necrotizing enterocolitis
Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity. NEC pathophysiology occurs in the hyper-reactive milieu of the premature gut after bacterial colonization. The resultant activation of the TLR4 pathway appears to be a strongly contributing factor. Advanc...
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ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2012
ISSN: 1336-0345
DOI: 10.4149/bll_2012_047